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What Is ‘Synthetic Marijuana’ and How Is It Made?
Rumors spread that it was legal and that it would mimic the effects of real cannabis. But when more and more people began suffering side effects (which in some cases led to death), concerns arose over synthetic cannabis, a designer drug made for those who prefer health risks to legal risks – or for those blind to the risks altogether.
What is Synthetic Cannabis?
Not to be confused with legal synthetic THC like Marinol, this cannabis doppelganger is anything but FDA-approved. Synthetic cannabis (also called synthetic cannabinds, SCs, or synncanns) hides under many monikers like K2 and Spice, as well as a label which reads “Not for human consumption.” New varieties are introduced with shuffled ingredients as a way of maintaining their legality. These products would sit inconspicuously on the shelves of smoke shops and gas stations, and of course the internet offered an even broader selection of products.
A synthetic cannabinoid is not a cannabis product, but a chemical analog that binds to the same system of receptors. THC, the primary psychoactive chemical in herbal cannabis, latches to CB1 receptors in the brain to produce a euphoric high, and synthetic cannabinoids also bind here, but with a much higher affinity.
Synthetic cannabinoids can be 2 to 100 times more potent than THC and induce severe side effects like vomiting, chest pain, increased heart rate, vision blackouts, headaches, kidney damage, agitation, high blood pressure, and psychosis. Significant withdrawal symptoms have also been reported.
John William Huffman, a Harvard graduate and organic chemistry professor at Clemson University, began synthesizing hundreds of novel cannabinoids in the mid-1980s for medical research purposes using funding from the National Institute of Drug Abuse (NIDA). They were intended as tools for understanding cannabinoid mechanisms, but in 2008 following the publication of his work, one cannabinoid called JWH-018 appeared thousands of miles away in a German forensic lab. They named it “Spice” and disseminated it to curious, experimentally-inclined customers.
Simple to manufacture with a remarkably short turnaround time, it didn’t take long for clandestine drug manufacturers to jump on the opportunity and open the market floodgates. Huffman’s response: “Someone opened Pandora’s box.”
How to Make Synthetic Cannabinoid Blends.
Synthetic cannabinoids are typically shipped overseas from China to manufacturers who prepare the blends using high-proof alcohol or acetone solvents. It’s basically a reverse-extraction: the synthetic molecules are dissolved in a solvent and introduced to its plantlike host material through a soaking or spraying process.


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